Dr. Ilona Szabłowska-Gadomska, an employee of the Laboratory for Cell Research and Application, will investigate the impact of the osteogenic differentiation process on changes in the protein profile of ADSC cells (Adipose Derived Stem Cells/Stromal Cells isolated from adipose tissue) and their secretome. Results of the co-financed project entitled "The impact of the osteogenic differentiation process and environmental conditions on the immunomodulatory profile of ADSC cells" may in the future contribute to a better understanding of the role of these cells in the body in physiological and pathological conditions, as well as a more safe and effective use in the clinic.

ADSC cells are located in adipose tissue. They can play a significant role in the development, and maintenance of tissue homeostasis, repair, and regeneration. Due to their abundance and relatively easy availability, the ability to multiply in vitro, and, above all, their immunomodulatory potential, they are a valuable tool in regenerative medicine. Substances secreted by ADSCs influence the functions of immune system cells and exert a strong immunosuppressive effect, constituting a specific "immunomodulation mediator".

The research will be carried out as part of the grant application submitted in the MINIATURA 7 competition for scientific activities, organized by the National Science Center.